Clinton is a city in Laurens County, South Carolina, United States. The population was 8,490 as of the 2010 census. It is part of the Greenvill…Clinton is a city in Laurens County, South Carolina, United States. The population was 8,490 as of the 2010 census. It is part of the Greenville–Mauldin–Easley Metropolitan Statistical Area in upstate South Carolina. Clinton is the home of Presbyterian College.